Revisiting Platinum-Based Anticancer Drugs to Overcome Gliomas
نویسندگان
چکیده
منابع مشابه
Polymeric biomaterials for the delivery of platinum-based anticancer drugs.
Since cisplatin, cis-diamminedichloroplatinum(ii), received FDA approval for use in cancer treatment in 1978, platinum-based drugs have been one of the most widely used drugs for the treatment of tumors in testicles, ovaries, head and neck. However, there are concerns associated with the use of platinum-based anticancer drugs, owing to severe side effects and drug resistance. In order to overco...
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In this article we review the biological activity of analogs of the antitumor drug cisplatin that contain chiral amine ligands. Interaction with DNA and formation of cross-links with adjacent purine bases are considered to be the crucial steps in the antitumor activity of this class of complexes. Because double-helical DNA has a chiral structure, interaction with enantiomeric complexes of plati...
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Approximately half of all patients who receive anticancer chemotherapy are treated with a platinum drug. Despite the widespread use of these drugs, the only cure that can be claimed is that of testicular cancer following cisplatin treatment. This article reviews some of our recent work on phenanthriplatin, a cisplatin derivative in which a chloride ion is replaced by phenanthridine, and on one ...
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C isplatin [cis-diamminedichloroplatinum (II)] is a highly active anticancer agent. This agent is curative against most testicular cancers and is highly active against a wide range of other tumor types, notably ovarian, bladder carcinoma, and non-small-cell lung cancer (1). Treatment failure is frequently caused by the development of resistance to cisplatin. Although the insensitive tumors gene...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2021
ISSN: 1422-0067
DOI: 10.3390/ijms22105111